Dendritic cell podosome dynamics does not depend on the F-actin regulator SWAP-70.

Dendritic cell podosome dynamics does not depend on the F-actin regulator SWAP-70.

Blog Article

In addition to classical adhesion structures like filopodia or focal adhesions, dendritic cells similar to macrophages and osteoclasts assemble highly dynamic F-actin structures called podosomes.They are involved in cellular processes such as extracellular matrix degradation, bone resorption by osteoclasts, and trans-cellular diapedesis of lymphocytes.Besides adhesion and migration, podosomes enable dendritic cells to degrade connective tissue by matrix metalloproteinases.SWAP-70 One-of-a-kind Hair-On Hides interacts with RhoGTPases and F-actin and regulates migration of dendritic cells.SWAP-70 deficient osteoclasts are impaired in Play Mat F-actin-ring formation and bone resorption.

In the present study, we demonstrate that SWAP-70 is not required for podosome formation and F-actin turnover in dendritic cells.Furthermore, we found that toll-like receptor 4 ligand induced podosome disassembly and podosome-mediated matrix degradation is not affected by SWAP-70 in dendritic cells.Thus, podosome formation and function in dendritic cells is independent of SWAP-70.